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Ivermectin meta   Meta Analysis
10/19 Early, Late, PrEP, PEP
Covid Analysis (Preprint) (meta analysis)
Ivermectin for COVID-19: real-time meta analysis of 63 studies
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• Meta analysis using the most serious outcome reported shows 66% [52‑76%] and 86% [75‑92%] improvement for early treatment and prophylaxis, with similar results after exclusion based sensitivity analysis (which excludes all of the GMK/BBC team studies), with primary outcomes, and after restriction to peer-reviewed studies or Randomized Controlled Trials.
• Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. 30 studies show statistically significant improvements in isolation.
• Results are very robust — in worst case exclusion sensitivity analysis 52 of 63 studies must be excluded to avoid finding statistically significant efficacy.
• While many treatments have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 24% of ivermectin studies show zero events in the treatment arm.
• Multiple treatments are typically used in combination, and other treatments could be more effective, including monoclonal antibodies which may be available in countries not recommending ivermectin (sotrovimab, casirivimab/imdevimab, and bamlanivimab/etesevimab).
• Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all variants. All practical, effective, and safe means should be used, including treatments, as supported by Pfizer [Pfizer, TrialSiteNews]. Denying the efficacy of treatments increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage.
Studies Prophylaxis Early treatment Late treatment PatientsAuthors
All studies 63 86% [75‑92%] 66% [52‑76%] 36% [21‑48%] 47,461 625
Peer-reviewed 44 86% [74‑93%] 71% [54‑82%] 38% [16‑55%] 17,126 466
With GMK/BBC exclusions 47 84% [69‑91%] 73% [63‑80%] 45% [22‑61%] 37,558 518
RCTs 30 84% [25‑96%] 62% [43‑75%] 20% [-6‑39%] 6,368 357
Percentage improvement with ivermectin treatment
• There is evidence of a negative publication bias, and the probability that an ineffective treatment generated results as positive as the 63 studies is estimated to be 1 in 122 billion.
Over 20 countries have adopted ivermectin for COVID-19. The evidence base is much larger and has much lower conflict of interest than typically used to approve drugs.
• All data to reproduce this paper and sources are in the appendix. See [Bryant, Hariyanto, Kory, Lawrie, Nardelli] for other meta analyses with similar results confirming efficacy.
Evidence base used for other COVID-19 approvals
MedicationStudiesPatientsImprovement
Budesonide (UK)11,77917%
Remdesivir (USA EUA)11,06331%
Casirivimab/i.. (USA EUA)179966%
Ivermectin evidence6347,437 65% [57‑73%]
All 124 studies   Meta Analysis
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.
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