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Ivermectin meta   Meta Analysis
7/20 Early, Late, PrEP, PEP
Covid Analysis (Preprint) (meta analysis)
Ivermectin for COVID-19: real-time meta analysis of 60 studies
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• Meta analysis using the most serious outcome reported shows 74% and 85% improvement for early treatment and prophylaxis (RR 0.26 [0.16-0.43] and 0.15 [0.08-0.25]), with similar results after exclusion based sensitivity analysis, restriction to peer-reviewed studies, and restriction to Randomized Controlled Trials.
• 64% and 96% lower mortality is observed for early treatment and prophylaxis (RR 0.36 [0.15-0.85] and 0.04 [0.00-0.59]). Statistically significant improvements are seen for mortality, hospitalization, cases, and viral clearance. 26 studies show statistically significant improvements in isolation.
Studies Prophylaxis Early treatment Late treatment PatientsAuthors
All studies 60 85% [75‑92%] 74% [57‑84%] 43% [26‑56%] 21,838 574
With exclusions 50 88% [75‑94%] 76% [66‑83%] 50% [28‑65%] 17,437 513
Peer-reviewed 39 88% [70‑95%] 75% [59‑84%] 43% [21‑59%] 11,593 408
Randomized Controlled Trials 30 84% [25‑96%] 67% [54‑76%] 30% [2‑50%] 5,206 358
Mortality results 23 96% [41‑100%] 64% [15‑85%] 59% [35‑74%] 10,797 236
Percentage improvement with ivermectin treatment
• The probability that an ineffective treatment generated results as positive as the 60 studies to date is estimated to be 1 in 193 billion (p = 0.0000000000052).
Heterogeneity arises from many factors including treatment delay, population, effect measured, variants, and regimens. The consistency of positive results is remarkable. Heterogeneity is low in specific cases, for example early treatment mortality.
• While many treatments have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 30% of ivermectin studies show zero events in the treatment arm.
• Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. All practical, effective, and safe means should be used. Those denying the efficacy of treatments share responsibility for the increased risk of COVID-19 becoming endemic; and the increased mortality, morbidity, and collateral damage.
• Administration with food, often not specified, may significantly increase plasma and tissue concentration.
• The evidence base is much larger and has much lower conflict of interest than typically used to approve drugs.
• All data to reproduce this paper and sources are in the appendix. See [Bryant, Hariyanto, Hill, Kory, Lawrie, Nardelli] for other meta analyses, all with similar results confirming effectiveness.
00.250.50.7511.251.51.752+Kory et al.69%0.31 [0.20-0.47]Improvement, RR [CI]Hill et al.75%0.25 [0.12-0.52]Bryant et al.62%0.38 [0.19-0.73]Lawrie et al.83%0.17 [0.08-0.35]Nardelli et al.79%0.21 [0.11-0.36]Hariyanto et al.69%0.31 [0.15-0.62]WHO (OR)81%0.19 [0.09-0.36]ivmmeta67%0.33 [0.21-0.51]Ivermectin meta analysis mortality resultsivmmeta.com 7/28/21Lower RiskIncreased Risk
Evidence base used for other COVID-19 approvals
MedicationStudiesPatientsImprovement
Budesonide (UK)11,77917%
Remdesivir (USA)11,06331%
Casiri/imdevimab (USA)179966%
Ivermectin evidence6021,814 70% [61‑76%]


All 102 studies   Meta Analysis
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.
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