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Other Treatments Global Adoption
All Studies   Meta Analysis   Recent: 
Ivermectin for COVID-19: real-time meta analysis of 82 studies
Covid Analysis (Preprint) (meta analysis)
22 Apr 2022    Source   PDF   Share   Tweet
• Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. All remain significant after exclusions. 53 studies from 48 independent teams in 22 different countries show statistically significant improvements in isolation (39 primary outcome, 36 most serious outcome).
• Meta analysis using the most serious outcome shows 63% [53‑72%] and 83% [74‑89%] improvement for early treatment and prophylaxis, with similar results after exclusion based sensitivity analysis, for primary outcomes, for peer-reviewed studies, and for RCTs.
• Results are very robust — in worst case exclusion sensitivity analysis 54 of 82 studies must be excluded to avoid finding statistically significant efficacy.
• While many treatments have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 24% of ivermectin studies show zero events in the treatment arm.
Multiple treatments are typically used in combination, which may be significantly more effective.
• No treatment, vaccine, or intervention is 100% available and effective for all variants. All practical, effective, and safe means should be used. Denying the efficacy of treatments increases mortality, morbidity, collateral damage, and endemic risk.
• Over 20 countries have adopted ivermectin for COVID-19. The evidence base is much larger and has much lower conflict of interest than typically used to approve drugs.
• All data to reproduce this paper and sources are in the appendix. See [Bryant, Hariyanto, Kory, Lawrie, Nardelli] for other meta analyses with similar results confirming efficacy.
Evidence base used for other COVID-19 approvals
MedicationStudiesPatientsImprovement
Molnupiravir (UK)177550%
Budesonide (UK)11,77917%
Remdesivir (USA EUA)11,06331%
Casirivimab/i.. (USA EUA)179966%
Ivermectin evidence82129,808 64% [56‑71%]
All Studies   Meta Analysis
Please send us corrections, updates, or comments. Vaccines and treatments are both valuable and complementary. All practical, effective, and safe means should be used. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases mortality, morbidity, collateral damage, and the risk of endemic status. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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