11 November 2020 - Late treatment study
Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
et al., PLoS ONE, 15:11, doi:10.1371/journal.pone.0242184 (Peer Reviewed)
Tiny 26 patient retrospective study of very late treatment with ivermectin 200 μg/kg, median 12 days after symptoms, not showing significant differences. Authors suggest the dose is too low and recommend evaluation of higher doses. All patients received HCQ which may reduce the potential benefit for adding ivermectin.
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risk of mechanical ventilation, 40.0% lower, RR 0.60, p = 0.67, treatment 3 of 13 (23.1%), control 5 of 13 (38.5%), NNT 6.5.
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risk of ICU admission, 33.3% lower, RR 0.67, p = 1.00, treatment 2 of 13 (15.4%), control 3 of 13 (23.1%), NNT 13, ICU at day 8.
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risk of no improvement at day 8, 33.3% higher, RR 1.33, p = 1.00, treatment 4 of 13 (30.8%), control 3 of 13 (23.1%).
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risk of no virological cure, 25.0% higher, RR 1.25, p = 1.00, treatment 5 of 13 (38.5%), control 4 of 13 (30.8%), tests done between days 3-5.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. |
Camprubí et al., 11/11/2020, retrospective, Spain, Europe, peer-reviewed, 9 authors, average treatment delay 12.0 days, dosage 200μg/kg single dose.
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