Small study of 24 consecutive patients in serious condition (9 days post symptoms, mean SpO2
87.4) using combined treatment with ivermectin, doxycycline, zinc, vitamin D, and vitamin C, showing no mortality or hospitalization with treatment. Two patients declined treatment and both died. This study uses a synthetic control arm.
Hazan et al., 7/7/2021, retrospective, USA, North America, preprint, 7 authors, dosage 12mg days 1, 4, 8, this trial uses multiple treatments in the treatment arm (combined with doxycycline, zinc, vitamin D, vitamin C) - results of individual treatments may vary.
risk of death, 85.9% lower, RR 0.14, p = 0.04, continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of hospitalization, 93.3% lower, RR 0.07, p = 0.001, continuity correction due to zero event (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.