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Ivermectin study #128   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 69% Imp. Relative Risk, 95% CI Disease progression -23% Malaysia Ministry of Health: Kenyataan Akhbar KPK 3 November 2021 – Hasil D.. c19ivermectin.com/itech.html Favors ivermectin Favors control
11/3 Late treatment study
Malaysia Ministry of Health (News)
Kenyataan Akhbar KPK 3 November 2021 – Hasil Dapatan Kajian Keberkesanan Rawatan Ivermectin Untuk Pesakit COVID-19 Berisiko Tinggi (I-TECH Study)
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RCT 490 hospitalized patients in Malaysia, showing no significant differences. There was only 13 deaths - 3 for ivermectin and 10 for control. Minimal details are available currently. Group sizes are not provided (241/249 are the closest counts that can produce the progression percentages provided).
If the same event rates continue, the trial would need to add only ~13% more patients to find a statistically significant reduction in mortality.
We note a stark contrast between the objective mortality results and the subjective progression results, and that the trial is open label. Some people involved in this trial may be subject to potential liability related to treatment decisions that could be partially mitigated by conflicting results. NCT04920942.
risk of death, 69.1% lower, RR 0.31, p = 0.09, treatment 3 of 241 (1.2%), control 10 of 249 (4.0%), odds ratio converted to relative risk.
risk of disease progression, 22.8% higher, RR 1.23, p = 0.30, treatment 51 of 241 (21.2%), control 43 of 249 (17.3%), odds ratio converted to relative risk.
This study is excluded in the after exclusion results of meta analysis: preliminary report with minimal details.
Malaysia Ministry of Health et al., 11/3/2021, Randomized Controlled Trial, Malaysia, Europe, preprint, 1 author, dosage 400μg/kg days 1-5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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