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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mechanical ventilation -152% Improvement Relative Risk Progression -4% Viral decay rate 66% primary c19ivermectin.com/krolewiecki.html Favors ivermectin Favors control
18 June 2021 - Early treatment study
Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial
Krolewiecki et al., EClinicalMedicine, doi:10.1016/j.eclinm.2021.100959 (Peer Reviewed)
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Proof of concept RCT with 30 ivermectin patients and 15 control patients, showing a concentration dependent antiviral activity, but no significant difference in clinical outcomes. There was no significant difference in viral load reduction between groups overall, but a significant difference was found in patients with higher median plasma ivermectin levels (72% vs. 42%, p=0.004). Mean ivermectin plasma concentration levels correlated with viral decay rate (r=0.47, p=0.02). The change in viral load is provided for the <160ng/mL and >160ng/mL groups, but not the overall treatment group. The corrigendum provides individual viral decay rates for computing the overall treatment group viral decay rate. NCT004381884. Authors published a corrigendum: [1].
risk of mechanical ventilation, 151.9% higher, RR 2.52, p = 1.00, treatment 1 of 27 (3.7%), control 0 of 14 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of progression, 3.7% higher, RR 1.04, p = 1.00, treatment 2 of 27 (7.4%), control 1 of 14 (7.1%).
viral decay rate, 65.6% lower, RR 0.34, p = 0.09, treatment 20, control 14, relative mean viral decay rate (corrigendum table 2).
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Krolewiecki et al., 6/18/2021, Randomized Controlled Trial, Argentina, South America, peer-reviewed, 23 authors, average treatment delay 3.5 days, dosage 600μg/kg days 1-5.
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