Computational molecular modeling screening and in vitro
analysis for inhibitory effects on SARS-CoV-2 specific 3CLpro
enzyme, showing that ivermectin blocked more than 85% of 3CLpro
activity of SARS-CoV-2. Antiviral activity of ivermectin mediated through the blocking of α/β1 importin has been previously established, this analysis suggests an additional antiviral mechanism of ivermectin for SARS-CoV-2 via inhibitory effects on 3CLpro
Mody et al., 1/20/2021, peer-reviewed, 9 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.