et al., Signa Vitae, doi:10.22514/sv.2021.043 (Peer Reviewed) (meta analysis)
Meta analysis of RCT mortality results showing RR 0.19, p
Nardelli et al., 3/11/2021, peer-reviewed, 8 authors.
risk of death, 79.5% lower, RR 0.21, p < 0.001, treatment 14 of 703 (2.0%), control 57 of 620 (9.2%), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.