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0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk Improvement at day 10 43% Improvement at day 5 16% primary Viral clearance 80% c19ivermectin.com Okumuş et al. NCT04646109 Ivermectin RCT LATE TREATMENT Favors ivermectin Favors control
Okumuş, 60 patient ivermectin late treatment RCT: 33% lower mortality [p=0.55], 43% better improvement [p=0.18], and 80% improved viral clearance [p=0.02] https://c19p.org/okumus
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Evaluation of the Effectiveness and Safety of Adding Ivermectin to Treatment in Severe COVID-19 Patients
Okumuş et al., BMC Infectious Diseases, doi:10.1186/s12879-021-06104-9 (preprint 1/12)
12 Jan 2021    Source   PDF   Share   Tweet
Small RCT for severe COVID-19 comparing the addition of ivermectin to SOC (low dose HCQ+AZ+favipiravir), with 30 treatment and 30 control patients in Turkey, showing lower mortality and faster clinical recovery. Authors also investigate the presence of gene mutations that alter ivermectin metabolism, predicting that ivermectin can be used safely without serious side effects in patients without MDR-1/ABCB1 and/or CYP3A4 gene mutation, and recommending monitoring and appropriate treatment if necessary when sequencing is unavailable. NCT04646109.
risk of death, 33.3% lower, RR 0.67, p = 0.55, treatment 6 of 30 (20.0%), control 9 of 30 (30.0%), NNT 10.
risk of no improvement at day 10, 42.9% lower, RR 0.57, p = 0.18, treatment 8 of 30 (26.7%), control 14 of 30 (46.7%), NNT 5.0.
risk of no improvement at day 5, 15.8% lower, RR 0.84, p = 0.60, treatment 16 of 30 (53.3%), control 19 of 30 (63.3%), NNT 10, primary outcome.
risk of no viral clearance, 80.0% lower, RR 0.20, p = 0.02, treatment 2 of 16 (12.5%), control 5 of 8 (62.5%), NNT 2.0, day 10.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Okumuş et al., 1/12/2021, Double Blind Randomized Controlled Trial, Turkey, Europe, peer-reviewed, 15 authors, dosage 200μg/kg days 1-5, 36-50kg - 9mg, 51-65kg - 12mg, 66-79kg - 15mg, >80kg 200μg/kg, trial NCT04646109.
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Late treatment
is less effective
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