Ozer, 120 patient ivermectin late treatment study: 75% lower mortality [p=0.09], 13% lower ventilation [p=0.2], and 9% longer hospitalization [p=0.09] https://c19p.org/ozer
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Effectiveness and Safety of Ivermectin in COVID‐19 Patients: A Prospective Study at A Safety‐Net Hospital
et al., Journal of Medical Virology, doi:10.1002/jmv.27469
Small prospective PSM study in the USA, showing 75% lower mortality with ivermectin treatment, without reaching statistical significance, significantly shorter ventilation and ICU time, and longer hospitalization time.Authors leave the statistically significant improvements in ventilation and ICU time out of the abtract and conclusions, and incorrectly state that there were no differences in other outcomes (there were no statistically significant differences) [nature.com]. Authors are ambiguous on the primary outcome, referring to the primary mortality outcome in one case, and "clinical outcomes, measured by the rate of intubation, length of hospital stay, and mechanical ventilation duration" in another case.The longer hospitalization time may be partially due to the greater mortality in the control group.
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risk of death, 75.0% lower, RR 0.25, p = 0.09, treatment 2 of 60 (3.3%), control 8 of 60 (13.3%), NNT 10.0, PSM.
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risk of mechanical ventilation, 12.6% lower, RR 0.87, p = 0.20, treatment 3 of 60 (5.0%), control 2 of 60 (3.3%), odds ratio converted to relative risk, PSM, multivariable.
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ventilation time, 83.3% lower, relative time 0.17, p = 0.002, treatment 60, control 60.
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risk of ICU admission, 48.7% lower, RR 0.51, p = 0.42, treatment 6 of 60 (10.0%), control 3 of 60 (5.0%), odds ratio converted to relative risk, PSM, multivariable.
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ICU time, 70.6% lower, relative time 0.29, p < 0.001, treatment 60, control 60.
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hospitalization time, 9.0% higher, relative time 1.09, p = 0.09, treatment 60, control 60, PSM, multivariable.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Ozer et al., 23 Nov 2021, prospective, USA, peer-reviewed, 12 authors, dosage 200μg/kg days 1, 3.
Late treatment
is less effective
is less effective
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