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0 0.5 1 1.5 2+ Ventilation 85% Improvement Relative Risk ICU admission 85% Improvement in Ct value 1% Viral clearance -11% primary Time to viral- 17% no CI c19ivermectin.com Pott-Junior et al. NCT04431466 Ivermectin RCT LATE Favors ivermectin Favors control
Pott-Junior, 31 patient ivermectin late treatment RCT: 85% lower ventilation [p=0.25], 85% lower ICU admission [p=0.25], and 1% improved viral clearance [p=1] https://c19p.org/pottjunior
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Use of ivermectin in the treatment of Covid-19: a pilot trial
Pott-Junior et al., Toxicology Reports, doi:10.1016/j.toxrep.2021.03.003, NCT04431466 (history)
9 Mar 2021    Source   PDF   Share   Tweet
Very small RCT with 4 control patients and 28 ivermectin patients split across 3 different dosage levels, showing lower (non-statistically significant) ICU admission with treatment. Authors suggest that ivermectin for SARS-CoV-2 is safe and reduces symptoms and viral load, and that the antiviral effect appears to be dose-dependent. NCT04431466 (history).
Retraction/censorship: this paper appears to have been censored at the request of the journal's founding editor [pubmed.ncbi.nlm.nih.gov]. An external review is mentioned but is not provided, and there is no reply from the authors, or indication that the authors were notified. Conclusions in this study are limited due to the small size, however we should consider all information in the context of the full body of research.
risk of mechanical ventilation, 85.2% lower, RR 0.15, p = 0.25, treatment 1 of 27 (3.7%), control 1 of 4 (25.0%), NNT 4.7.
risk of ICU admission, 85.2% lower, RR 0.15, p = 0.25, treatment 1 of 27 (3.7%), control 1 of 4 (25.0%), NNT 4.7.
relative improvement in Ct value, 0.8% better, RR 0.99, p = 1.00, treatment 27, control 3.
risk of no viral clearance, 11.1% higher, RR 1.11, p = 1.00, treatment 10 of 27 (37.0%), control 1 of 3 (33.3%), primary outcome.
time to viral-, 16.7% lower, relative time 0.83, treatment 27, control 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pott-Junior et al., 9 Mar 2021, Randomized Controlled Trial, Brazil, peer-reviewed, 10 authors, average treatment delay 8.0 days, dosage 200μg/kg single dose, dose varies in three arms 100, 200, 400μg/kg, trial NCT04431466 (history).
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