RCT 100 patients in Lebanon, showing significantly lower viral load at day 3, and lower hospitalization. All patients also took zinc and vitamin C. ChiCTR2000033627.
Samaha et al., 1/16/2021, Randomized Controlled Trial, Lebanon, Middle East, peer-reviewed, 16 authors, dosage 12mg single dose, 45–64kg, 65–84kg, and >85kg patients received 9mg, 12mg, or 150µg/kg respectively.
risk of hospitalization, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 50 (0.0%), control 3 of 50 (6.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of fever at day 3, 90.9% lower, RR 0.09, p = 0.004, treatment 1 of 50 (2.0%), control 11 of 50 (22.0%).
relative improvement in Ct value at day 3, 68.3% lower, RR 0.32, p < 0.001, treatment 50, control 50.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.