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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Symptomatic case 50% Improvement Relative Risk Case 6% primary c19ivermectin.com/seet.html Favors ivermectin Favors vitamin C
14 April 2021 - Prophylaxis study
Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an open-label randomized trial
Seet et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.04.035 (Peer Reviewed)
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Prophylaxis RCT in Singapore with 3,037 low risk patients, showing lower serious cases, lower symptomatic cases, and lower confirmed cases of COVID-19 with all treatments (ivermectin, HCQ, PVP-I, and Zinc + vitamin C) compared to vitamin C.
The ivermectin dosage was low for 42 days prophylaxis - only a single dose of 200µg/kg, with a maximum of 12mg.
Meta-analysis of vitamin C in 6 previous trials shows a benefit of 16%, so the actual benefit of ivermectin, HCQ, and PVP-I may be higher. Cluster RCT with 40 clusters.
There were no hospitalizations and no deaths. NCT04446104.
risk of symptomatic case, 49.8% lower, RR 0.50, p < 0.001, treatment 32 of 617 (5.2%), control 64 of 619 (10.3%), NNT 19.
risk of case, 5.8% lower, RR 0.94, p = 0.61, treatment 398 of 617 (64.5%), control 433 of 619 (70.0%), NNT 18, adjusted per study, odds ratio converted to relative risk, model 6.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Seet et al., 4/14/2021, Cluster Randomized Controlled Trial, Singapore, Asia, peer-reviewed, 15 authors, dosage 12mg single dose, 200µg/kg, maximum 12mg, this trial compares with another treatment - results may be better when compared to placebo.
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