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0 0.5 1 1.5 2+ Mortality 100% Improvement Relative Risk Ventilator free days 48% primary Ventilation time 38% ICU free days 43% ICU time 38% GI complications while ve.. 78% c19ivermectin.com Shimizu et al. Ivermectin for COVID-19 LATE TREATMENT Favors ivermectin Favors control
Shimizu, 88 patient ivermectin late treatment study: 100% lower mortality [p=0.001], 48% lower ventilation [p=0.03], 43% lower ICU admission [p=0.06], and 78% lower progression [p=0.03] https://c19p.org/shimizu
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Ivermectin administration is associated with lower gastrointestinal complications and greater ventilator-free days in ventilated patients with COVID-19: A propensity score analysis
Shimizu et al., Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2021.12.024
31 Dec 2021    Source   PDF   Share   Tweet
Retrospective 88 ventilated COVID-19 patients in Japan, 39 treated with ivermectin within 3 days of admission, showing significantly reduced incidence of GI complications and mortality, and increased ventilator-free days with treatment.
risk of death, 99.9% lower, HR 0.001, p < 0.001, treatment 0 of 39 (0.0%), control 8 of 49 (16.3%), NNT 6.1, adjusted per study, Cox proportional hazard regression.
ventilator free days, 47.9% lower, OR 0.52, p = 0.03, treatment 39, control 49, adjusted per study, proportional odds logistic regression, primary outcome, RR approximated with OR.
ventilation time, 38.5% lower, relative time 0.62, p < 0.001, treatment 39, control 49.
ICU free days, 42.8% lower, OR 0.57, p = 0.06, treatment 39, control 49, adjusted per study, proportional odds logistic regression, RR approximated with OR.
ICU time, 37.5% lower, relative time 0.62, p < 0.001, treatment 39, control 49.
GI complications while ventilated, 77.9% lower, RR 0.22, p = 0.03, treatment 39, control 49, adjusted per study, Cox proportional hazard regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shimizu et al., 12/31/2021, retrospective, Japan, Asia, peer-reviewed, 11 authors, study period December 2020 - May 2021, dosage 200μg/kg days 1, 14.
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Late treatment
is less effective
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