Why COVID-19 is not so spread in Africa: How does Ivermectin affect it?

Ivermectin study #85 of 113 Meta Analysis

3/26 Prophylaxis study

Tanioka et al., medRxiv, doi:10.1101/2021.03.26.21254377 (Preprint)
Why COVID-19 is not so spread in Africa: How does Ivermectin affect it?

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Retrospective study of the 31 onchocerciasis-endemic countries using the community-directed treatment with ivermectin (CDTI) and the 22 non-endemic countries in Africa, showing significantly lower mortality per capita in the countries using ivermectin.

Tanioka et al., 3/26/2021, retrospective, ecological study, multiple countries, multiple regions, preprint, 3 authors, dosage 200μg/kg, dose varied, typically 150-200μg/kg.

risk of death, 88.2% lower, RR 0.12, p = 0.002, relative mean mortality per million.

This study is excluded in meta analysis: not a typical trial, analysis of African countries that used or did not use ivermectin prophylaxis for parasitic infections.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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