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160 ivermectin COVID-19 studies, 110 peer reviewed, 82 comparing treatment and control groups. Recent:
Zheng
Babalola
Albariqi
Delandre
Reis
Aminpour.
Ivermectin has been officially adopted for early treatment in all or part of 22 countries (39 including non-government medical organizations). Submit updates/corrections.
 
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Apr 27
Late Babalola et al., Research Square, doi:10.21203/rs.3.rs-1576399/v1 (Preprint) Ivermectin is associated with increase in SPO2 in hypoxemic SARS-CoV-2 patients: pharmacodynamic profile and correlates
Details   Extended analysis of , showing significantly faster and greater improvement in SpO2 with ivermectin treatment.
Apr 22
Early, Late, PrEP, PEP Covid Analysis (Preprint) (meta analysis)
meta-analysis v189
Ivermectin for COVID-19: real-time meta analysis of 82 studies
Details   • Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. All remain significant after exclusions. 53 studies from 48 independent teams in 22 differ..
Apr 13
Review Marinos, A. (Review) (Preprint)
review
The Problem With The TOGETHER Trial
Details   Analysis of serious problems with the Together Trial. Also see .
May 31
Animal Zheng et al., International Journal of Pharmaceutics, doi:10.1016/j.ijpharm.2022.121719
animal study
Red blood cell-hitchhiking mediated pulmonary delivery of ivermectin: Effects of nanoparticle properties
Details   In Vitro and mouse study proposing a method for improving ivermectin pharmacokinetics and bioavailability using delivery via red blood cells.
Apr 6
Late Ravikirti et al., Research Square, doi:10.21203/rs.3.rs-1522422/v1 (Preprint)
death, ↓2.8%, p=0.82
Association between Ivermectin treatment and mortality in Covid-19: A hospital-based case-control study
Details   Retrospective 965 late stage (44% severe, 27% ICU) hospitalized patients in India, showing no significant difference with ivermectin treatment. Overall mortality was very high, suggesting very late treatment. The low non-weight-adjusted d..
Apr 2
In Vitro Delandre et al., Pharmaceuticals, doi:10.3390/ph15040445 (In Vitro)
In Vitro
Antiviral Activity of Repurposing Ivermectin against a Panel of 30 Clinical SARS-CoV-2 Strains Belonging to 14 Variants
Details   In Vitro study with 30 COVID-19 strains from 14 variants, showing stronger efficacy with ivermectin compared to CQ and remdesivir, and relatively homogeneous efficacy with ivermectin regardless of strain/variant, in contrast to results fo..
Mar 30
News Reis et al., New England Journal of Medicine, doi:10.1056/NEJMoa2115869 (News)
news
Effect of Early Treatment with Ivermectin among Patients with Covid-19
Details   The Together RCT can be found at . Studies are listed under the date they first became available (August 6, 2021 for this study).
Mar 25
In Silico Aminpour et al., Computation, doi:10.3390/computation10040051
In Silico
In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds
Details   In Silico analysis identifying strong or moderate affinity bindings for ivermectin to multiple sites on the spike protein, CD147 and α7nAChr, which may provide effective competitive binding for all variants of SARS-CoV-2. Ivermectin had t..
Mar 21
Meta Bitterman et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2022.3079 Comparison of Trials Using Ivermectin for COVID-19 Between Regions With High and Low Prevalence of Strongyloidiasis
Details   Analysis of a small subset of 12 ivermectin trials showing a relationship with efficacy and strongyloides prevalence. This analysis is confounded by treatment delay, dose, conflicts of interest, and other factors, and the effect disappear..
Mar 18
Animal Albariqi et al., International Journal of Pharmaceutics, doi:10.1016/j.ijpharm.2022.121688
animal study
Pharmacokinetics and Safety of Inhaled Ivermectin in Mice as a Potential COVID-19 Treatment
Details   Mouse study of an inhaled ivermectin formulation, showing high concentrations in the lung and bronchoalveolar lavage fluid, exceeding the required concentration for efficacy based on in vitro studies.
Mar 11
Dosing Albariqi et al., Journal of Aerosol Medicine and Pulmonary Drug Delivery, doi:10.1089/jamp.2021.0059 (Dosing)
dosing study
Preparation and Characterization of Inhalable Ivermectin Powders as a Potential COVID-19 Therapy
Details   Creation and analysis of an inhalable dry powder formulation of ivermectin for COVID-19.
Mar 7
News Harper, P. (News)
news
Professor tied to altered Andrew Hill paper also prepared 'Ivermectin Evidence' for World Health Organisation
Details   Forensic analysis of the Hill meta analysis discovering an unlisted author potentially connected to changes and also related to the WHO ivermectin analysis. Author notes that "the person who allegedly edited the Andrew Hill paper ..
Mar 4
News Lawrie, T. (News)
news
A Letter to Dr. Andrew Hill
Details   Documentary about the external forces changing the conclusions of the Hill et al. meta analysis, and the subsequent negative impact around the world.
Mar 2
Late Soto et al., PLOS ONE, doi:10.1371/journal.pone.0264789
death, ↑41.0%, p=0.001
Mortality and associated risk factors in patients hospitalized due to COVID-19 in a Peruvian reference hospital
Details   Retrospective 1,418 very late stage (46% mortality) patients in Peru, showing higher mortality with ivermectin. There is strong confounding by indication, for example 48% of patients with baseline SpO2 <70% were treated compared with 22% ..
Feb 28
Late Efimenko et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.096
death, ↓69.2%, p<0.0001
Treatment with Ivermectin Is Associated with Decreased Mortality in COVID-19 Patients: Analysis of a National Federated Database
Details   PSM retrospective 41,608 patients in the USA, 1,072 treated with ivermectin and 40,536 treated with remdesivir, showing lower mortality with ivermectin treatment. This study was presented at a conference (IMED 2021). Submissions were peer..
Feb 25
Late Thairu et al., Research Square, doi:10.21203/rs.3.rs-1373673/v1 (Preprint)
death, ↓87.9%, p=0.12
A comparison of Ivermectin and Non Ivermectin based regimen for covid 19 in Abuja: effects on virus clearance, Days-to-Discharge and Mortality
Details   PSM retrospective 87 patients in Nigeria, 61 treated with ivermectin, showing lower mortality, faster recovery, and faster viral clearance with ivermectin treatment. All patients received zinc and vitamin C. A synergistic effect was seen ..
Feb 18
News Lim et al., JAMA, doi:10.1001/jamainternmed.2022.0189 (data 11/3/21) (News)
news
Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial
Details   The I-TECH RCT can be found at . Studies are listed under the date they first became available (November 3, 2021 for this study).
Feb 2
Early Manomaipiboon et al., Research Square, doi:10.21203/rs.3.rs-1290999/v1 (Preprint)
no recov., ↓43.5%, p=0.26
Efficacy and safety of ivermectin in the treatment of mild-to-moderate COVID-19 infection: A randomized, double blind, placebo, controlled trial
Details   Small RCT with 72 low-risk patients in Thailand, showing improved recovery with ivermectin, without statistical significance. All patients recovered and there was no escalation of care in either group. There were no adverse events.
Jan 31
In Vitro Kowa News Release (News) (In Vitro)
news
Antiviral effect of ivermectin confirmed for omicron
Details   Kowa reports that ivermectin is effective for omicron in In Vitro research.
Jan 24
Early de Jesús Ascencio-Montiel et al., Archives of Medical Research, doi:10.1016/j.arcmed.2022.01.002
death/hosp., ↓59.0%, p<0.0001
A Multimodal Strategy to Reduce the Risk of Hospitalization/death in Ambulatory Patients with COVID-19
Details   Retrospective 28,048 COVID+ patients in Mexico, 7,898 receiving a treatment kit including low dose ivermectin, AZ, aspirin, and acetaminophen, shower lower mortality/hospitalization for those receiving the kit. Delivery of the treatment k..
Jan 23
In Vitro Liu et al., bioRxiv, doi:10.1101/2022.01.20.477147 (Preprint) (In Vitro)
In Vitro
SARS-CoV-2 Viral Genes Compromise Survival and Functions of Human Pluripotent Stem Cell-derived Cardiomyocytes via Reducing Cellular ATP Level
Details   In Vitro study showing that ivermectin and meclizine may be protective for heart muscle damage due to SARS-CoV-2.
Jan 20
In Silico Parvez et al., arXiv:2201.08176 [q-bio.OT] (Preprint)
In Silico
Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity and possible therapeutics
Details   In Silico analysis of the omicron variant and 10 treatments reported effective for previous variants, predicting that all will be effective for omicron, with ivermectin showing the best results.
Jan 18
Late Zubair et al., Monaldi Archives for Chest Disease, doi:10.4081/monaldi.2022.2062
death, ↑9.0%, p=1.00
The effect of ivermectin on non-severe and severe COVID-19 disease and gender-based difference of its effectiveness
Details   Retrospective 188 hospitalized patients in Pakistan, 90 treated with ivermectin, showing no significant differences with treatment. The ivermectin group had more severe disease (66% vs 58%, with 6x higher risk for severe disease patients)..
Jan 13
Early Tyson et al., Preprint (Preprint)
death, ↓99.8%, p<0.0001
Low Rates of Hospitalization and Death in 4,376 COVID-19 Patients Given Early Ambulatory Medical and Supportive Care. A Case Series and Observational Study.
Details   Retrospective 4,376 patients with mild/moderate COVID-19 in the USA treated with multiple medications including HCQ/ivermectin, favipiravir, vitamin C, D, quercetin, zinc, mAbs, budesonide, dexamethasone, prednisone, and colchicine (exact..
Dec 31
2021
Early Abbas et al., Indian Journal of Pharmaceutical Sciences, doi:10.36468/pharmaceutical-sciences.spl.416
death, ↑4.0%, p=1.00
The Effect of Ivermectin on Reducing Viral Symptoms in Patients with Mild COVID-19
Details   RCT 99 ivermectin and 103 control low risk patients in China, up to 7 days from symptom onset, showing statistically significant improvement in recovery with treatment, and non-statistically significant improvements in recovery time and..
Dec 31
2021
PrEPPEP Kerr et al., Research Gate, doi:10.13140/RG.2.2.26793.52327 (Preprint)
death, ↓45.0%, p=0.046
COVID-19 In-Hospital Mortality Rate is Reduced by Prophylactic Use of Ivermectin: Findings From a City-Wide, Prospective Observational Study Using Propensity Score Matching (PSM)
Details   PSM retrospective 378 hospitalized patients in Brazil, showing lower mortality for patients that were on ivermectin prophylaxis before admission (not taking into account the lower risk of being hospitalized shown in the related larger stu..
Dec 31
2021
Late Shimizu et al., Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2021.12.024
death, ↓99.9%, p<0.001
Ivermectin administration is associated with lower gastrointestinal complications and greater ventilator-free days in ventilated patients with COVID-19: A propensity score analysis
Details   Retrospective 88 ventilated COVID-19 patients in Japan, 39 treated with ivermectin within 3 days of admission, showing significantly reduced incidence of GI complications and mortality, and increased ventilator-free days with treatment.
Dec 30
2021
Review Semiz, S., Biomolecular Concepts, doi:10.1515/bmc-2021-0017 (Review)
review
SIT1 transporter as a potential novel target in treatment of COVID-19
Details   Review of the potential connections between SLC6A20/SIT1, ACE2, Type 2 Diabetes, and COVID-19 severity. This provides another potential mechanism of action for ivermectin as a partial agonist of glycine-gated chloride channels, interferin..
Dec 29
2021
Late Mustafa et al., Exploratory Research in Clinical and Social Pharmacy, doi:10.1016/j.rcsop.2021.100101
death, ↓63.7%, p=0.09
Pattern of medication utilization in hospitalized patients with COVID-19 in three District Headquarters Hospitals in the Punjab province of Pakistan
Details   Retrospective 444 hospitalized patients in Pakistan, showing lower mortality with ivermectin treatment in unadjusted results, not reaching statistical significance. Ivermectin was mostly used with patients in severe condition. Dose ranged..
Dec 28
2021
Late Baguma et al., Research Square, doi:10.21203/rs.3.rs-1193578/v1 (Preprint)
death, ↓96.8%, p=0.31
Characteristics of the COVID-19 patients treated at Gulu Regional Referral Hospital, Northern Uganda: A cross-sectional study
Details   Retrospective COVID+ hospitalized patients in Uganda, showing no statistically significant difference in mortality with ivermectin, however there were only 7 patients receiving ivermectin.
Dec 21
2021
Review Zaidi et al., The Journal of Antibiotics, doi:10.1038/s41429-021-00491-6 (Review)
review
The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
Details   Extensive review of 20 mechanisms of action of ivermectin for SARS-CoV-2.
Dec 13
2021
Late Jamir et al., Cureus, doi:10.7759/cureus.20394
death, ↑53.0%, p=0.13
Determinants of Outcome Among Critically Ill Police Personnel With COVID-19: A Retrospective Observational Study From Andhra Pradesh, India
Details   Retrospective 266 COVID-19 ICU patients in India, showing significantly lower mortality with PVP-I oral gargling and topical nasal use, and non-statistically significant higher mortality with ivermectin and lower mortality with remdesivir.
Dec 11
2021
PrEPPEP Kerr et al., Cureus, doi:10.7759/cureus.21272 (preprint 12/11/2021)
death, ↓70.0%, p<0.0001
Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching
Details   PSM retrospective 220,517 patients in Brazil,133,051 taking ivermectin as part of a citywide prophylaxis program, showing significantly lower hospitalization and mortality with treatment. CAAE:47124221.2.0000.5485. Additional results are ..
Dec 4
2021
Safety Wentzel et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab466.728
safety analysis
Systematic Review and Meta-Analysis of Ivermectin Safety Profile in COVID-19 Trials
Details   Systematic review and meta-analysis of safety in ivermectin COVID-19 trials, showing no significant difference in adverse events between treatment and control arms. Authors conclude that ivermectin is safe and well-tolerated.
Dec 1
2021
Review Behl et al., Science of The Total Environment, doi:10.1016/j.scitotenv.2021.152072 (Review)
review
CD147-spike protein interaction in COVID-19: Get the ball rolling with a novel receptor and therapeutic target
Details   Review of the cluster of differentiation 147 (CD147) transmembrane protein as an entry route for SARS-CoV-2, correlation with observed characteristics of COVID-19, and relevant potential therapeutics including azithromycin, melatonin, sta..
Nov 30
2021
In Vitro Jitobaom et al., Research Square, doi:10.21203/rs.3.rs-1069947/v1 (Preprint) (In Vitro)
In Vitro
Synergistic Anti-SARS-CoV-2 Activity of Repurposed Anti-Parasitic Drug Combinations
Details   In Vitro study showing a strong synergistic effect of combinations of ivermectin, niclosamide, and chloroquine, with >10x reduction in IC50 compared to individual drugs.
Nov 26
2021
Late Ferreira et al., Revista da Associação Médica Brasileira, doi:10.1590/1806-9282.20210661
death, ↑5.0%, p=1.00
Outcomes associated with Hydroxychloroquine and Ivermectin in hospitalized patients with COVID-19: a single-center experience
Details   Retrospective 230 hospitalized patients in Brazil showing no significant difference with ivermectin treatment. Authors note that the treatments were more likely to be offered to sicker patients. Authors indicate that they do not know when..
Nov 23
2021
Late Ozer et al., Journal of Medical Virology, doi:10.1002/jmv.27469
death, ↓75.0%, p=0.09
Effectiveness and Safety of Ivermectin in COVID‐19 Patients: A Prospective Study at A Safety‐Net Hospital
Details   Small prospective PSM study in the USA, showing 75% lower mortality with ivermectin treatment, without reaching statistical significance, significantly shorter ventilation and ICU time, and longer hospitalization time. Authors leave the s..
Nov 17
2021
PrEPPEP Samajdar et al., Journal of the Association of Physicians India, 69:11
cases, ↓79.8%, p<0.0001
Ivermectin and Hydroxychloroquine for Chemo-Prophylaxis of COVID-19: A Questionnaire Survey of Perception and Prescribing Practice of Physicians vis-a-vis Outcomes
Details   Physician survey in India with 164 ivermectin prophylaxis, 129 HCQ prophylaxis, and 81 control patients, showing significantly lower COVID-19 cases with treatment. Details of the treatment and control groups and the definition of cases ar..
Nov 9
2021
Late Stone et al., Research Square, doi:10.21203/rs.3.rs-1048271/v1 (Preprint) Rapid increase of SpO2 on room air for 34 severe COVID-19 patients after ivermectin-based combination treatment: 55-62% normalization within 12-24 hours
Details   Retrospective severe COVID-19 patients in Zimbabwe treated with ivermectin, doxycycline, and zinc. For 34 with SpO2 tracking, there was rapid improvement in SpO2, with 55% recovery towards SpO2=97 within 12 hours. For all 92 severe cases,..
Nov 3
2021
Late Lim et al., JAMA, doi:10.1001/jamainternmed.2022.0189 (data 11/3/21)
death, ↓69.0%, p=0.09
Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial
Details   RCT 490 late stage (>65% lung change chest radiography at baseline) hospitalized patients in Malaysia, showing no significant differences. Mortality was 1.2% for ivermectin vs. 4% for control. If the same event rates continue, the trial w..
Oct 30
2021
Late Rezk et al., Zagazig University Medical Journal, doi:10.21608/zumj.2021.92746.2329
death, ↓80.0%, p=0.50
miRNA-223-3p, miRNA- 2909 and Cytokines Expression in COVID-19 Patients Treated with Ivermectin
Details   Prospective 320 hospitalized moderate COVID-19+ patients in Egypt, 160 treated with ivermectin, showing lower mortality, improved recovery, and decreased cytokine expression with treatment. All patients were treated with HCQ. 7890/26-8-20..
Oct 28
2021
PrEPPEP Verma et al., Indian Journal of Community Health, 33:3 Assessing Knowledge, Attitude, and Practices towards Ivermectin Pre-exposure Prophylaxis for COVID-19 among Health Care Workers
Details   Survey of 306 healthcare workers involved in the medication of COVID-19 patients in India. 71% indicated that ivermectin had a protective effect for COVID-19.
Oct 20
2021
Review Low et al., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, doi:10.1016/j.bbadis.2021.166294 (Review)
review
Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication
Details   Review of the antiviral characteristics of ivermectin and mechanisms of action. Authors note that ivermectin has proven effective for HIV-1, Adenovirus, flu, SARS-CoV, and more; due to genomic similarity between SARS-CoV-2 and SARS-CoV, t..
Oct 19
2021
Early Borody et al., TrialSite News (Preprint)
death, ↓92.3%, p=0.03
Combination Therapy For COVID-19 Based on Ivermectin in an Australian Population
Details   Retrospective 600 PCR+ outpatients in Australia treated with ivermectin, zinc, and doxycycline, showing significantly lower mortality and hospitalization with treatment. This trial uses a synthetic control group, and the preliminary repor..
Oct 15
2021
In Vitro Segatori et al., Viruses, doi:10.3390/v13102084 (In Vitro)
In Vitro
Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients
Details   Gene expression analysis of nasopharyngeal swabs of COVID-19 positive and negative patients, and in vitro study supporting the use of ivermectin and atorvastatin for COVID-19, and the efficacy of ivermectin at clinically relevant dosages...
Oct 14
2021
In Vitro Jitobaom et al., Research Square, doi:10.21203/rs.3.rs-941811/v1 (Preprint) (In Vitro)
In Vitro
Favipiravir and Ivermectin Showed in Vitro Synergistic Antiviral Activity against SARS-CoV-2
Details   In Vitro study showing a strong synergistic effect of ivermectin and favipiravir. Combining multiple antiviral drugs with different mechanisms of action helps to minimize drug resistance and toxicity. For ivermectin alone, IC50 for Calu-3..
Oct 14
2021
News Goodkin, M. (News)
news
Are Major Ivermectin Studies Designed for Failure?
Details   Discussion of flaws in ivermectin trials creating a bias towards not finding an effect.
Oct 7
2021
Review Fordham et al., OSF Preprints, doi:10.31219/osf.io/mp4f2 (Review) (Preprint)
review
The uses and abuses of systematic reviews
Details   Analysis of defects in the Popp et al. meta analysis.
Oct 5
2021
In Silico Francés-Monerris et al., Physical Chemistry Chemical Physics, doi:10.1039/D1CP02967C
In Silico
Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
Details   In Silico molecular dynamics study showing that ACE2 and ACE2/RBD aggregates form persistent interactions with ivermectin.
Oct 2
2021
N/A TrialSite News (News)
news
Committed to Medical Evidence, a Prominent Ivermectin Group is Eradicated from the Memories of Cyberspace
Details   Report on Twitter's censorship of the British Ivermectin Recommendation Development group.
Oct 1
2021
Late Babalola et al., Research Square, doi:10.21203/rs.3.rs-950352/v1 (Preprint) A Randomized Controlled Trial of Ivermectin Monotherapy Versus Hydroxychloroquine, Ivermectin, and Azithromycin Combination Therapy in Covid-19 Patients in Nigeria
Details   Small RCT with 61 patients in Nigeria, all patients treated with ivermectin, zinc, and vitamin C, showing no significant improvements in recovery with the addition of HCQ+AZ. PACTR202108891693522.
Sep 23
2021
Early Mayer et al., Frontiers in Public Health, doi:10.3389/fpubh.2022.813378 (preprint 9/23/2021)
death, ↓55.1%, p<0.0001
Safety and Efficacy of a MEURI Program for the Use of High Dose Ivermectin in COVID-19 Patients
Details   Retrospective 21,232 patients in Argentina, 3,266 assigned to ivermectin treatment, showing lower mortality with treatment. Greater benefits were seen for patients >40, and a dose dependent response was found. For more discussion see .
Sep 7
2021
News Scheim, D., TrialsSite News (News)
news
Merck’s deadly Vioxx playbook, redux: a debunked smear campaign against its competing drug—the FDA-approved, Nobel prize-honored ivermectin
Details   Discussion of Merck's ivermectin statements and past actions related to Vioxx raising significant concerns.
Sep 6
2021
Early Buonfrate et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2021.106516 (preprint 9/6/2021)
hosp., ↑210.7%, p=0.47
High dose ivermectin for the early treatment of COVID-19 (COVER study): a randomised, double-blind, multicentre, phase II, dose-finding, proof of concept trial
Details   Early terminated 89 patient RCT with 29 high dose and 32 very high dose ivermectin patients, showing dose dependent viral load reduction, although not reaching statistical significance due to early termination. Since most patients have lo..
Sep 3
2021
Early Okogbenin et al., Nigerian Postgraduate Medical Journal, doi:10.4103/npmj.npmj_532_21 Clinical characteristics, treatment modalities and outcome of coronavirus disease 2019 patients treated at thisday dome isolation and treatment centre, federal capital territory Abuja, Nigeria
Details   Retrospective 300 COVID-19 patients in Nigeria treated with ivermectin, zinc, vitamin C, and azithromycin, reporting no deaths. Authors conclude that early treatment is critical.
Sep 2
2021
Meta Marik et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001443 (meta analysis)
meta-analysis
Ivermectin, A Reanalysis of the Data
Details   Updated meta analysis showing no significant change if Elgazzar et al. is excluded.
Sep 2
2021
Meta Neil et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001450 (meta analysis)
meta-analysis
Bayesian Hypothesis Testing and Hierarchical Modeling of Ivermectin Effectiveness
Details   Updated Bayesian analysis of a subset of ivermectin trials showing that there is strong evidence to support a causal link between ivermectin and COVID-19 severity and mortality, and that the result is robust in sensitivity analysis, inclu..
Aug 19
2021
In Silico González-Paz et al., Biophysical Chemistry, doi:10.1016/j.bpc.2021.106677
In Silico
Comparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach
Details   In Silico analysis of the components of ivermectin (avermectin-B1a and avermectin-B1b), suggesting different and complementary inhibitory activity of each component, with an affinity of avermectin-B1b for viral structures, and of avermect..
Aug 17
2021
In Silico González-Paz et al., Journal of Molecular Liquids, doi:10.1016/j.molliq.2021.117284
In Silico
Structural Deformability Induced in Proteins of Potential Interest Associated with COVID-19 by binding of Homologues present in Ivermectin: Comparative Study Based in Elastic Networks Models
Details   In Silico elastic network model analysis of ivermectin components (avermectin-B1a and avermectin-B1b) providing a biophysical and computational perspective of proposed multi-target activity of ivermectin for COVID-19.
Aug 16
2021
Review Kory, P., Substack (Review) (Preprint)
review
Summary of the Evidence for Ivermectin in COVID-19
Details   Summary of the evidence base for ivermectin and COVID-19 including in vitro and in silico studies, animal studies, pharmacologic studies, clinical observation and experience, observational controlled trials, randomized controlled trials, ..
Aug 12
2021
Late Elavarasi et al., medRxiv, doi:10.1101/2021.08.10.21261855 (Preprint)
death, ↓19.6%, p=0.12
Clinical features, demography and predictors of outcomes of SARS-CoV-2 infection in a tertiary care hospital in India - a cohort study
Details   Retrospective 2017 hospitalized patients in India, showing lower mortality with ivermectin treatment in unadjusted results. No group details are provided and this result is subject to confounding by indication.
Aug 12
2021
N/A Pedroso et al., The Brazilian Journal of Infectious Diseases, doi:10.1016/j.bjid.2021.101603 Self-prescribed Ivermectin use is associated with a lower rate of seroconversion in health care workers diagnosed with COVID, in a dose-dependent response
Details   Retrospective 45 healthcare workes in Brazil, showing lower creation of antibodies with multiple doses of ivermectin, which may be expected due to the antiviral activity as demonstrated in multiple studies. Authors appear unaware of these..
Aug 10
2021
Early La Pampa, Argentina (News)
death, ↓27.4%
La Pampa expondrá a la comunidad científica los resultados del Programa de Intervención Monitoreado de Ivermectina
Details   News report on the use of ivermectin in La Pampa, Argentina, showing lower mortality with treatment.
Aug 6
2021
Review Kow et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001441 (Review)
review
Pitfalls in Reporting Sample Size Calculation Across Randomized Controlled Trials Involving Ivermectin for the treatment of COVID-19
Details   Review of sample size calculations in ivermectin RCTs, showing that existing RCTs are very underpowered.
Aug 6
2021
Early Reis et al., New England Journal of Medicine, doi:10.1056/NEJMoa2115869 (results released 8/6/2021)
death, ↓12.0%, p=0.68
Effect of Early Treatment with Ivermectin among Patients with Covid-19
Details   Many major issues including multiple impossible numbers, blinding failure, randomization failure, and many protocol violations , as detailed below. Submit Updates or Corrections Also see: Fraudulent Trial On Ivermectin Published By The Wo..
Aug 5
2021
In Silico Rana et al., Research Square, doi:10.21203/rs.3.rs-755838/v1 (Preprint)
In Silico
A Computational Study of Ivermectin and Doxycycline Combination Drug Against SARS-CoV-2 Infection
Details   In silico study showing strong binding affinity of ivermectin and doxycycline for SARS-CoV-2 main protease 3CLpro, and increased binding affinity for the combination of both.
Aug 3
2021
Review Santin et al., New Microbes and New Infections, doi:10.1016/j.nmni.2021.100924 (Review)
review
Ivermectin: a multifaceted drug of Nobel prize-honored distinction with indicated efficacy against a new global scourge, COVID-19
Details   Review concluding that the evidence supports worldwide use of ivermectin for COVID-19, complementary to immunization. Authors note that it is likely non-epitope specific, possibly retaining efficacy with new viral strains. They note that ..
Jul 31
2021
Early, Late Sathi et al., Journal of Cardiovascular Disease Research, doi:10.31838/jcdr.2021.12.05.11 Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19
Details   Prospective study of 85 COVID-19 patients including 8 ICU patients treated with ivermectin, HCQ, and AZ, showing all patients improving except for one patient that died 3 days after admission. Authors recommend early treatment. There was ..
Jul 28
2021
Meta Popp et al., Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD015017.pub2 (Preprint) (meta analysis)
meta-analysis
Ivermectin for preventing and treating COVID-19
Details   This meta analysis is designed to exclude most studies. Authors select a small subset of studies, with a majority of results based on only 1 or 2 studies. Authors split up studies which dilutes the effects and results in a lack of statist..
Jul 25
2021
Early Ontai et al., Epidemiology International Journal, doi:10.23880/eij-16000217 Early multidrug treatment of SARS-CoV-2 (COVID-19) and decreased case fatality rates in Honduras
Details   Report on the nationwide implementation of multi-drug COVID-19 inpatient and outpatient treatment protocols in Honduras, showing a case fatality rate decrease from 9.33% to 2.97%. No decrease was seen in Mexico, a similar Latin American c..
Jul 24
2021
News World Ivermectin Day (News)
news
World Ivermectin Day
Details   Joint event by 22 worldwide organizations.
Jul 23
2021
Safety Mansour et al., International Immunopharmacology, doi:10.1016/j.intimp.2021.108004
safety analysis
Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study
Details   Safety analysis of an inhaled lyophilized ivermectin formulation, showing 127-fold increase in drug solubility, and identifying safe dosage levels in rats.
Jul 16
2021
News FLCCC Alliance and British Ivermectin Recommendation Development Group (News)
news
Joint Statement of the FLCCC Alliance and British Ivermectin Recommendation Development Group on Retraction of Early Research on Ivermectin
Details   News release noting that ivermectin remains effective after excluding Elgazzar et al. Given the large magnitude effects and 61 studies, excluding one study with ~3% of patients does not significantly change the evidence base.
Jul 12
2021
Meta Neil et al., ResearchGate, doi:0.13140/RG.2.2.31800.88323 (Preprint) (meta analysis)
meta-analysis
Bayesian Meta Analysis of Ivermectin Effectiveness in Treating Covid-19 Disease
Details   Bayesian analysis of a subset of ivermectin trial data concluding that there is overwhelming evidence to support a causal link between ivermectin, COVID-19 severity, and mortality.
Jul 8
2021
In Silico Muthusamy et al., Journal of Virology & Antiviral Research
In Silico
Virtual Screening Reveals Potential Anti-Parasitic Drugs Inhibiting the Receptor Binding Domain of SARS-CoV-2 Spike protein
Details   In Silico study identifying 32 anti-parisitic compounds effectively inhibiting the RBD of the SARS-CoV-2 spike protein, with ivermectin being one of the top compounds.
Jul 8
2021
News Together Trial (News)
news
Together Trial removes mortality and adverse event outcomes, and sublingual administration mid-trial
Details   Together Trial removes mortality and adverse event outcomes, and sublingual administration mid-trial.
Jul 7
2021
Late Hazan et al., medRxiv, doi:10.1101/2021.07.06.21259924 (Preprint)
death, ↓86.2%, p=0.04
Effectiveness of Ivermectin-Based Multidrug Therapy in Severe Hypoxic Ambulatory COVID-19 Patients
Details   Small study of 24 consecutive patients in serious condition (9 days post symptoms, mean SpO2 87.4) using combined treatment with ivermectin, doxycycline, zinc, vitamin D, and vitamin C, showing no mortality or hospitalization with treatme..
Jul 3
2021
News Open Letter, Statement of Concern and Request for Retraction, re: Roman et al. (News)
news
Open Letter, Statement of Concern and Request for Retraction
Details   Open letter signed by 40 physicians detailing errors and flaws in the Roman et al. meta analysis, and requesting retraction.
Jul 2
2021
Review Adegboro et al., African Journal of Clinical and Experimental Microbiology, doi:10.4314/ajcem.v22i3.2 (Review)
review
A review of the anti-viral effects of ivermectin
Details   Review of the antiviral effects of ivermectin.
Jul 2
2021
Early Vallejos et al., BMC Infectious Diseases, doi:10.1186/s12879-021-06348-5
death, ↑33.5%, p=0.70
Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind, placebo-controlled trial
Details   RCT with 501 relatively low-risk outpatients in Argentina showing hospitalization OR 0.65 [0.32-1.31]. With only 7% hospitalization, this trial is underpowered. The trial primarily includes low-risk patients that recover quickly without t..
Jun 30
2021
Review Turkia, M., ResearchGate, doi:10.13140/RG.2.2.16973.36326 (Review) (Preprint)
review
A Continuation of a Timeline of Ivermectin-Related Events in the COVID-19 Pandemic [June 30, 2021]
Details   An extension of the ivermectin timeline covering April - June 2021, including WHO's role and funding, Gavi, COVAX, Trusted News Initiative, International Fact-Checking Network, the role of private philantrophy, Frontiers, comparison to th..
Jun 28
2021
N/A Roman et al., Clinical Infectious Diseases, doi:10.1093/cid/ciab591 (preprint 5/25/21) (meta analysis)
meta-analysis
Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials
Details   This is a severely flawed meta analysis. An open letter signed by 40 physicians detailing errors and flaws, and requesting retraction, can be found at [ trialsitenews.com ] . See also [ bird-group.org ] . Authors cherry-pick to include on..
Jun 25
2021
Review Jagiasi et al., The International Journal of Clinical Practice, doi:10.1111/ijcp.14574 (Review)
review
Variation in therapeutic strategies for the management of severe COVID-19 in India- A nationwide cross-sectional survey
Details   Survey of medication use for severe COVID-19 in India, showing 33% adoption of ivermectin as of January 2021.
Jun 22
2021
News Misiones Ministry of Public Health (News)
news
Results from ivermectin use from the Misiones Ministry of Public Health
Details   News report on ivermectin use in Misiones, Argentina, showing significantly lower hospitalization and mortality, and a dose-dependent effect with improved results for those taking 0.6mg/kg.
Jun 18
2021
Review Lind et al., Journal of General Internal Medicine, doi:10.1007/s11606-021-06948-6 (Review)
review
Increase in Outpatient Ivermectin Dispensing in the US During the COVID-19 Pandemic: A Cross-Sectional Analysis
Details   CDC analysis of ivermectin prescriptions in the US suggesting that, while national health authority recognition is delayed in that country, many physicians are aware of the efficacy demonstrated in clinical trials.
Jun 18
2021
Early Krolewiecki et al., EClinicalMedicine, doi:10.1016/j.eclinm.2021.100959
ventilation, ↑151.9%, p=1.00
Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial
Details   Proof of concept RCT with 30 ivermectin patients and 15 control patients, showing a concentration dependent antiviral activity, but no significant difference in clinical outcomes. There was no significant difference in viral load reductio..
Jun 17
2021
Meta Bryant et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001402 (preprint 3/11/21) (meta analysis)
death, ↓62.0%, p=0.005
Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines
Details   Systematic review, meta analysis, and trial sequential analysis of 24 RCTs finding mortality RR 0.38 [0.19-0.73]. An update notes potentially inaccurate data collection and/or reporting in some sources .
Jun 15
2021
Early Aref et al., International Journal of Nanomedicine, doi:10.2147/IJN.S313093
recov. time, ↓63.2%, p=0.0001
Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19
Details   RCT 114 patients in Egypt, 57 treated with ivermectin mucoadhesive nanosuspension intranasal spray, showing faster recovery and viral clearance with treatment. NCT04716569.
Jun 6
2021
N/A Hariyanto et al., Reviews In Medical Virology, doi:10.1002/rmv.2265 (meta analysis)
death, ↓69.0%, p=0.001
Ivermectin and outcomes from Covid-19 pneumonia: A systematic review and meta-analysis of randomized clinical trial studies
Details   Systematic review and meta analysis of 19 RCTs showing mortality RR 0.31 [0.15-0.62].
Jun 3
2021
Review Wang et al., medRxiv, doi:10.1101/2021.06.01.21258147 (Review) (Preprint)
review
Minimum manufacturing costs, national prices and estimated global availability of new repurposed therapies for COVID-19
Details   Analysis of the manufacturing cost of several COVID-19 medications, showing a cost of $0.55 per course of ivermectin, including excipients, formulation, tax, and profit.
Jun 2
2021
Late Abd-Elsalam et al., Journal of Medical Virology, doi:10.1002/jmv.27122
death, ↓25.0%, p=0.70
Clinical Study Evaluating the Efficacy of Ivermectin in COVID-19 Treatment: A Randomized Controlled Study
Details   RCT 164 hospitalized patients in Egypt showing lower mortality and shorter hospitalization, but without statistical significance. There were no serious adverse effects. Authors suggest the low dosage may have resulted in lower efficacy th..
May 31
2021
PrEPPEP Mondal et al., Journal of the Indian Medical Association, 119:5
symp. case, ↓87.9%, p=0.006
Prevalence of COVID-19 Infection and Identification of Risk Factors among Asymptomatic Healthcare Workers: A Serosurvey Involving Multiple Hospitals in West Bengal
Details   Retrospective 1,470 healthcare workers in India, showing significantly lower risk of symptomatic COVID-19 with ivermectin prophylaxis.
May 18
2021
In Vitro Mountain Valley MD (Preprint) (In Vitro)
In Vitro
Mountain Valley MD Receives Successful Results From BSL-4 COVID-19 Clearance Trial on Three Variants Tested With Ivectosol™
Details   In Vitro and mouse study with human ACE2 cells, using solubilized ivermectin with Ivectosol™, showing antiviral effect with B.1.1.7, B.1.351, and P.1 variants of SARS-CoV-2. The ability to inject ivermectin potentially reduces the onset o..
May 12
2021
News FLCCC Public Statement (News)
news
FLCCC Alliance Statement on the Irregular Actions of Public Health Agencies and the Widespread Disinformation Campaign Against Ivermectin
Details   Analysis of the ivermectin recommendations from WHO and others, and a call to action for all citizens, scientists, and media to counter false information. Whistleblowers can submit anonymous reports and images at the bottom of this page.
May 10
2021
Early Faisal et al., The Professional Medical Journal, doi:10.29309/TPMJ/2021.28.05.5867
no recov., ↓68.4%, p=0.005
Potential use of azithromycin alone and in combination with ivermectin in fighting against the symptoms of COVID-19
Details   RCT 100 outpatients in Pakistan, 50 treated with ivermectin, showing faster recovery with ivermectin. All patients received AZ, zinc, vitamin C, vitamin D, and paracetemol. Details of randomization were not provided. No mortality or hospi..
May 5
2021
In Vitro Zatloukal et al. (News) (In Vitro)
news
News report on In Vitro results from the research institute of Prof. Zatloukal
Details   News report on In Vitro results from the research institute of Prof. Zatloukal, showing that "ivermectin was able to reduce virus replication by a factor of 1,000 even at low concentrations".
May 5
2021
In Silico Qureshi et al., Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2021.1906750
In Silico
Mechanistic insights into the inhibitory activity of FDA approved ivermectin against SARS-CoV-2: old drug with new implications
Details   In Silico study showing inhibition of importin-α1 by ivermectin, which disrupts SARS-CoV-2 replication.
May 4
2021
Meta Karale et al., medRxiv, doi:10.1101/2021.04.30.21256415 (Preprint) (meta analysis)
meta-analysis
A Meta-analysis of Mortality, Need for ICU admission, Use of Mechanical Ventilation and Adverse Effects with Ivermectin Use in COVID-19 Patients
Details   Systematic review and meta analysis with 30 studies included in quantitative analysis, showing mortality OR 0.39 [0.22-0.70]. Subgroup analysis of trials with severity data showed mortality OR 0.10 [0.03-0.33] for mild/moderate cases.
May 3
2021
Early Merino et al., Preprint (Preprint)
hosp., ↓74.4%, p<0.001
Ivermectin and the odds of hospitalization due to COVID-19: evidence from a quasi-experimental analysis based on a public intervention in Mexico City
Details   Analysis of Mexico City's use of an ivermectin-based medical kit, showing significantly lower hospitalization with use. Authors use logistic-regression models with matched observations, including adjustments for age, sex, COVID severity, ..
Apr 30
2021
Review Kory et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001377 (Review)
review
Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19
Details   Review of ivermectin trials and epidemiological data, concluding that ivermectin is effective for prophylaxis and treatment, and should be globally and systematically deployed in the prevention and treatment of COVID-19. An update notes p..
Apr 29
2021
Late Ahsan et al., Cureus, doi:10.7759/cureus.14761
death, ↓50.0%, p=0.03
Clinical Variants, Characteristics, and Outcomes Among COVID-19 Patients: A Case Series Analysis at a Tertiary Care Hospital in Karachi, Pakistan
Details   Retrospective 165 hospitalized patients in Pakistan showing unadjusted lower mortality with combined ivermectin and doxycycline treatment. Details of the ivermectin group compared to other patients are not provided, however ivermectin was..
Apr 19
2021
Review DiNicolantonio et al., Open Heart, doi:10.1136/openhrt-2021-001655 (Review)
review
Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect activation of systemic glycine receptors
Details   Review suggesting that the effectiveness of ivermectin in the cytokine storm phase of COVID-19 may be, at least in part, an anti-inflammatory effect mediated by increased activation of glycine receptors on leukocytes and possibly vascular..
Apr 17
2021
Early Loue et al., J. Infectious Diseases and Epidemiology, doi:10.23937/2474-3658/1510202
death, ↓70.0%, p=0.34
Ivermectin and COVID-19 in Care Home: Case Report
Details   Small quasi-randomized (patient choice) study with 25 PCR+ patients in a nursing home offered ivermectin, of which 10 chose to be treated. The mean age was 83.5 in the treatment group and 81.8 in the control group. There was lower mortali..
Apr 16
2021
PrEPPEP Morgenstern et al., Cureus, doi:10.7759/cureus.17455 (preprint 4/16/2021)
hosp., ↓80.0%, p=0.50
Ivermectin as a SARS-CoV-2 Pre-Exposure Prophylaxis Method in Healthcare Workers: A Propensity Score-Matched Retrospective Cohort Study
Details   Propensity matched retrospective prophylaxis study of healthcare workers in the Dominican Republic showing significantly lower cases with treatment, and no hospitalization with treatment (versus 2 in the PSM matched control group). The ca..
Apr 15
2021
In Silico Schöning et al., Research Square, doi:10.21203/rs.3.rs-379291/v1 (Preprint)
In Silico
Highly-transmissible Variants of SARS-CoV-2 May Be More Susceptible to Drug Therapy Than Wild Type Strains
Details   In Silico study of ivermectin treatment predicting greater efficacy for variants with higher R0.
Apr 14
2021
PrEPPEP Seet et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.04.035
symp. case, ↓49.8%, p=0.0009
Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an open-label randomized trial
Details   Prophylaxis RCT in Singapore with 3,037 low risk patients, showing lower serious cases, lower symptomatic cases, and lower confirmed cases of COVID-19 with all treatments (ivermectin, HCQ, PVP-I, and Zinc + vitamin C) compared to vitamin ..
Apr 10
2021
In Silico Bello et al., Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2021.1911857
In Silico
Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targets
Details   In Silico analysis finding that the in vitro activity of ivermectin may explained by acting as an inhibitor of importin-α, dimeric 3CLpro, and Nsp9.
Apr 3
2021
Review Turkia, M., Research Gate (Review) (Preprint)
review
A timeline of ivermectin-related events in the COVID-19 pandemic
Details   An extensive timeline of ivermectin-related events from April 2020 to March 2021 including studies, news, health authority decisions, biased news coverage, and censorship. The author concludes that in a broader historical perspective, the..
Apr 1
2021
Early Mourya et al., Int. J. Health and Clinical Research
viral+, ↓89.4%, p<0.0001
Comparative Analytical Study of Two Different Drug Regimens in Treatment of Covid 19 Positive Patients in Index Medical College Hospital and Research Center, Indore, India
Details   Retrospective 100 patients in India with 50 treated with ivermectin, and SOC for all patients including HCQ+AZ, showing much higher viral clearance with ivermectin. Baseline clinical status was worse in the control group. Time of testing ..
Mar 30
2021
Review Wehbe et al., Front. Immunol., doi:10.3389/fimmu.2021.663586 (Review)
review
Repurposing Ivermectin for COVID-19: Molecular Aspects and Therapeutic Possibilities
Details   Review of how ivermectin was identified for use in COVID-19, mechanisms of action, and selected clinical trials.
Mar 30
2021
Early Chahla et al., Research Square, doi:10.21203/rs.3.rs-495945/v1 (original preprint 3/30) (Preprint)
no disch., ↓86.9%, p=0.004
Cluster Randomised Trials - Ivermectin Repurposing For COVID-19 Treatment Of Outpatients With Mild Disease In Primary Health Care Centers
Details   Cluster RCT outpatients in Argentina showing significantly faster recovery with ivermectin. There were no deaths. Cluster RCT where outpatients in Tucumán were assigned to the ivermectin group and outpatients from San Miguel de Tucumán an..
Mar 29
2021
Meta Kow et al., Pharmacological Reports, doi:10.1007/s43440-021-00245-z (meta analysis)
meta-analysis
The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis
Details   Small meta analysis of 6 RCTs showing mortality OR 0.21 [0.11-0.42]. Authors do not include two more recent RCTs with mortality results, 10 other studies with mortality results, and a total of 42 other studies including other outcomes. Au..
Mar 26
2021
PrEPPEP Tanioka et al., medRxiv, doi:10.1101/2021.03.26.21254377 (Preprint)
death, ↓88.2%, p=0.002
Why COVID-19 is not so spread in Africa: How does Ivermectin affect it?
Details   Retrospective study of the 31 onchocerciasis-endemic countries using the community-directed treatment with ivermectin (CDTI) and the 22 non-endemic countries in Africa, showing significantly lower mortality per capita in the countries us..
Mar 25
2021
In Silico Udofia et al., Network Modeling Analysis in Health Informatics and Bioinformatics, doi:10.1007/s13721-021-00299-2
In Silico
In silico studies of selected multi-drug targeting against 3CLpro and nsp12 RNA-dependent RNA-polymerase proteins of SARS-CoV-2 and SARS-CoV
Details   In Silico analysis finding that ivermectin had the highest binding energy against the 3CLpro of SARS-CoV-2 and RdRps of both SARS-CoV and SARS-CoV-2.
Mar 25
2021
In Silico Choudhury et al., Future Medicine, doi:10.2217/fvl-2020-0342
In Silico
Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach
Details   In Silico analysis finding that ivermectin has high binding affinity for the SARS-CoV-2 viral spike protein, main protease, replicase, and human TMPRSS2 receptors.
Mar 25
2021
Late Huvemek Press Release (Preprint)
no improv., ↓31.6%, p=0.28
Kovid-19 - Huvemek® Phase 2 clinical trial
Details   Phase 2 results from a multicenter RCT of hospitalized patients in Bulgaria showing faster viral clearance, greater clinical improvement, and improved biomarkers with treatment. Ivermectin was taken on an empty stomach, potentially reduci..
Mar 24
2021
Review Yagisawa et al., The Japanese Journal of Antibiotics, 74-1, Mar 2021 (Review)
review
Global trends in clinical studies of ivermectin in COVID-19
Details   Review of ivermectin for COVID-19. Authors note that Kitasato University's project was expanded in response to the results of Caly et al. which had left questions regarding in vivo therapeutic levels, and the results of those studies were..
Mar 21
2021
Early Emmerich et al., Int. J. Environ. Res. Public Health, doi:10.3390/ijerph18073371 (Preprint) Comparisons between the Neighboring States of Amazonas and Pará in Brazil in the Second Wave of COVID-19 Outbreak and a Possible Role of Early Ambulatory Treatment
Details   Comparison between the two largest neighboring states in Brazil, Amazonas and Pará, showing more than 5 times lower mortality in Pará during the second wave when the Pará government supported early treatment and Amazonas did not, compared..
Mar 18
2021
Late Del Franco et al., Journal of Biomedical Research and Clinical Investigation, doi:10.31546/2633-8653.1008 Ivermectin in Long-Covid Patients: A Retrospective Study
Details   Retrospective 856 patients previously admitted to hospital for COVID-19 in Argentina, finding that ivermectin improved recovery from "long covid" symptoms.
Mar 17
2021
In Vitro Dinesh Kumar et al., Antimicrobial Agents and Chemotherapy, doi:10.1128/AAC.01543-21 (preprint 3/17/2021) (In Vitro)
In Vitro
Moxidectin and ivermectin inhibit SARS-CoV-2 replication in Vero E6 cells but not in human primary airway epithelium cells
Details   In Vitro study showing moxidectin and ivermectin exhibited antiviral activity in Vero E6 cells. Authors indicate that no statistically significant effect was seen in Calu-3/PBEC cells, however Figure 3 shows a dose dependent reduction wit..
Mar 12
2021
Early Roy et al., medRxiv, doi:10.1101/2021.03.08.21252883 (Preprint)
recov. time, ↓5.6%, p=0.87
Outcome of Different Therapeutic Interventions in Mild COVID-19 Patients in a Single OPD Clinic of West Bengal: A Retrospective study
Details   Retrospective database analysis of 56 mild COVID-19 patients, all treated with vitamin C, vitamin D, and zinc, comparing ivermectin + doxycycline (n=14), AZ (n=13), HCQ (n=14), and SOC (n=15), finding that all groups recover quickly, and ..
Mar 11
2021
Meta Nardelli et al., Signa Vitae, doi:10.22514/sv.2021.043 (meta analysis)
death, ↓79.5%, p<0.0001
Crying wolf in time of Corona: the strange case of ivermectin and hydroxychloroquine. Is the fear of failure withholding potential life-saving treatment from clinical use?
Details   Meta analysis of RCT mortality results showing RR 0.19, p < 0.00001.
Mar 11
2021
Meta Scheim et al., OSF Preprints (Preprint) (meta analysis)
meta-analysis
Ivermectin sales in Valle del Cauca, Colombia, patterns of AEs, and other background re López-Medina et al. 2021
Details   Analysis of several issues with López-Medina et al. including the atypical adverse effects in the control arm and population use of ivermectin.
Mar 11
2021
Meta Scheim et al., OSF Preprints (Preprint) (meta analysis)
meta-analysis
Protocol violations in López-Medina et al.: 38 switched ivermectin (IVM) and placebo doses, failure of blinding, widespread IVM sales OTC in Cali, and nearly identical AEs for the IVM and control groups
Details   Report on protocol violations in López-Medina et al.
Mar 10
2021
In Silico Kern et al., Frontiers in Pharmacology, doi:10.3389/fphar.2021.625678
In Silico
Modeling of SARS-CoV-2 Treatment Effects for Informed Drug Repurposing
Details   Modeling study analyzing timing and dosing regimens of hydroxychloroquine, lopinavir/ritonavir, ivermectin, artemisinin, and nitazoxanide. The greatest benefits were seen when treatments were given immediately at the time of diagnosis. Au..
Mar 10
2021
In Vitro Yesilbag et al., Virus Research, doi:10.1016/j.virusres.2021.198384 (In Vitro)
In Vitro
Ivermectin also inhibits the replication of bovine respiratory viruses (BRSV, BPIV-3, BoHV-1, BCoV and BVDV) in vitro
Details   In Vitro study showing that ivermectin can inhibit infection of bovine respiratory disease viral agents BCoV, BPIV-3, BVDV, BRSV and BoHV-1 at the concentrations of 2.5 and 5 μM and in a dose-dependent manner.
Mar 9
2021
Late Pott-Junior et al., Toxicology Reports, doi:10.1016/j.toxrep.2021.03.003
ventilation, ↓85.2%, p=0.25
Use of ivermectin in the treatment of Covid-19: a pilot trial
Details   Very small RCT with 4 control patients and 28 ivermectin patients split across 3 different dosage levels, showing lower (non-statistically significant) ICU admission with treatment. Authors suggest that ivermectin for SARS-CoV-2 is safe a..
Mar 8
2021
Early Chamie-Quintero et al., OSF Preprints (Preprint) Ivermectin for COVID-19 in Peru: 14-fold reduction in nationwide excess deaths, p=.002 for effect by state, then 13-fold increase after ivermectin use restricted
Details   Analysis of ivermectin use in Peru concluding that ivermectin most likely caused a 14 times reduction in excess deaths in Peru, prior to a 13 times increase after reversal of ivermectin use. Authors conclude that the results strongly sugg..
Mar 8
2021
Late Guzman et al., medRxiv, doi:10.1101/2021.03.04.21252084 (Preprint)
death, ↓19.0%, p=0.35
Factors associated with increased mortality in critically ill COVID-19 patients in a Mexican public hospital: the other faces of health system oversaturation
Details   Retrospective 196 critically ill patients in Mexico. Patients overlap with the existing RCT by Beltran-Gonzalez (NCT04391127). This preprint shows a larger treated population and greater (non-statistically significant) improvement with iv..
Mar 8
2021
Late Galan et al., Pathogens and Global Health, doi:10.1080/20477724.2021.1890887 Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infection
Details   RCT 168 very late stage severe condition hospitalized patients comparing CQ, HCQ, and ivermectin not showing significant differences. Authors were unable to add a control arm due to ethical issues. Authors claim that "the mortality r..
Mar 5
2021
Safety Descotes, J., ImmunoSafe Consultance (Preprint)
safety analysis
Medical Safety of Ivermectin
Details   Safety analysis of >350 articles showing that ivermectin has an excellent safety profile. The author notes that "no severe adverse event has been reported in dozens of completed or ongoing studies involving thousands of participants..
Mar 4
2021
Early López-Medina et al., JAMA, doi:10.1001/jama.2021.3071
death, ↓66.8%, p=0.50
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial
Details   An open letter, signed by >100 physicians, concluding this study is fatally flawed can be found at [ jamaletter.com ] . This is a phone survey based RCT with low risk patients, 200 ivermectin and 198 control, showing lower mortality, lowe..
Mar 1
2021
In Silico Saha et al., Structural Chemistry, doi:10.1007/s11224-021-01776-0 (preprint 3/1) (Preprint)
In Silico
The Binding mechanism of ivermectin and levosalbutamol with spike protein of SARS-CoV-2
Details   In Silico analysis predicting that ivermectin has a large binding affinity for the SARS-CoV-2 spike protein. Three different computer modeling techniques show that ivermectin can inhibit SARS-CoV-2 entrance via hACE2.
Feb 23
2021
Late Beltran Gonzalez et al., Infectious Disease Reports, doi:10.3390/idr14020020 (preprint 2/23/2021)
death, ↓14.4%, p=1.00
Efficacy and Safety of Ivermectin and Hydroxychloroquine in Patients with Severe COVID-19: A Randomized Controlled Trial
Details   RCT late stage severe condition (93% SOFA ≥ 2, 96% APACHE ≥ 8) high comorbidity hospitalized patients in Mexico with 36 low dose ivermectin and 37 control patients not finding significant differences. NCT04391127. Another study reports re..
Feb 20
2021
News BIRD Meeting 20th February 2021 (News)
news
BIRD Meeting 20th February 2021
Details   The British Ivermectin Recommendation Development (BIRD) panel, with dozens of multi-national scientists & doctors, issued sweeping recommendations for the immediate global use of ivermectin.
Feb 16
2021
Early Elalfy et al., J. Med. Virol., doi:10.1002/jmv.26880
viral+, ↓86.9%, p<0.0001
Effect of a combination of Nitazoxanide, Ribavirin and Ivermectin plus zinc supplement (MANS.NRIZ study) on the clearance of mild COVID-1
Details   Non-randomized controlled trial with 62 mild and early moderate patients with home treatment with ivermectin + nitazoxanide + ribavirin + zinc, showing significantly faster viral clearance.
Feb 15
2021
PrEPPEP Behera et al., Cureus 13:8, doi:10.7759/cureus.16897 (preprint 2/15/21)
cases, ↓83.0%, p<0.001
Prophylactic Role of Ivermectin in Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare Workers
Details   Prospective prophylaxis study with 3,532 healthcare workers, 2,199 receiving two-dose ivermectin prophylaxis, showing adjusted relative risk of confirmed COVID-19 with treatment 0.17 [0.12-0.23] p<0.001. 186 patients took only the first d..
Feb 12
2021
Early Biber et al., medRxiv, doi:10.1101/2021.05.31.21258081 (results 2/12/21) (Preprint)
hosp., ↓70.2%, p=0.34
Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19, A double-blind, randomized placebo-controlled trial
Details   Double blind RCT for mild-moderate COVID-19 outpatients in Israel showing significantly faster reduction in viral load with treatment, and lower hospitalization with treatment. The one treatment hospitalization was a few hours after treat..
Feb 10
2021
Late Lima-Morales
death, ↓77.7%, p<0.001
Effectiveness of a multidrug therapy consisting of ivermectin, azithromycin, montelukast and acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico
Details   Prospective trial of 768 COVID-19 outpatients in Mexico, 481 treated with ivermectin, AZ, montelukast, and aspirin, and 287 control patients with various treatments, showing significantly lower mortality and hospitalization, and significa..
Feb 2
2021
Early Mohan et al., Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2021.08.021 (preprint 2/2/2021)
no recov., ↓62.5%, p=0.27
Single-dose oral ivermectin in mild and moderate COVID-19 (RIVET-COV): a single-centre randomized, placebo-controlled trial
Details   RCT in India with low risk patients, comparing 24mg ivermectin, 12mg ivermectin, and placebo showing non-statistically significant improvements in recovery and PCR+ status (day 5 both arms, day 7 24mg only) with treatment, and showing gre..
Jan 29
2021
Meta Cobos-Campos et al., Clin. Res. Trials, 2021, doi:10.15761/CRT.1000333 (meta analysis)
meta-analysis
Potential use of ivermectin for the treatment and profilaxis of SARS-CoV-2 infection: Efficacy of ivermectin for SARS-CoV-2
Details   Review finding that there appears to be sufficient evidence to recommend ivermectin for the treatment of COVID-19, especially in the early stages of the disease.
Jan 27
2021
Meta Castaneda-Sabogal et al., medRxiv, doi:10.1101/2021.01.26.21250420 (Preprint) (meta analysis)
meta-analysis
Outcomes of Ivermectin in the treatment of COVID-19: a systematic review and meta-analysis
Details   Meta analysis of a very small subset of studies exhibiting very high bias and significant flaws. Some of the problems: - As of the publication date, there are 35 studies, authors include only 4. (They list 5, but two are the same study, p..
Jan 25
2021
In Silico Eweas et al., Frontiers in Microbiology, doi:10.3389/fmicb.2020.592908
In Silico
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
Details   Molecular docking analysis showing that ivermectin efficiently binds to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2; therefore, it might be involved in inhibiting the entry of the virus into the host ..
Jan 23
2021
Animal Errecalde et al., Journal of Pharmaceutical Sciences, doi:10.1016/j.xphs.2021.01.017
animal study
Safety and Pharmacokinetic Assessments of a Novel Ivermectin Nasal Spray Formulation in a Pig Model
Details   Animal study of a novel spray formulation of ivermectin, showing an advantage of the spray formulation in terms of fast attainment of high and persistent ivermectin concentrations in nasopharyngeal tissue.
Jan 21
2021
Early Chamie-Quintero et al., Preprint, doi:10.2139/ssrn.3765018 (Preprint) Sharp Reductions in COVID-19 Case Fatalities and Excess Deaths in Peru in Close Time Conjunction, State-By-State, with Ivermectin Treatments
Details   Analysis of ivermectin usage within states in Peru showing sharp reductions in COVID-19 deaths corresponding to the usage of ivermectin treatment.
Jan 20
2021
In Vitro Mody et al., Communications Biology, doi:10.1038/s42003-020-01577-x (In Vitro)
In Vitro
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
Details   Computational molecular modeling screening and in vitro analysis for inhibitory effects on SARS-CoV-2 specific 3CLpro enzyme, showing that ivermectin blocked more than 85% of 3CLpro activity of SARS-CoV-2. Antiviral activity of ivermectin..
Jan 19
2021
Late Shahbaznejad et al., Clinical Therapeutics, doi:10.1016/j.clinthera.2021.04.007 (partial results available 1/19)
death, ↑197.1%, p=1.00
Effect of ivermectin on COVID-19: A multicenter double-blind randomized controlled clinical trial
Details   RCT in Iran showing shorter time to recovery and shorter hospitalization time with ivermectin. There were no adverse effects. There was one death in the treatment group, the patient was in critical condition at baseline and died within 24..
Jan 19
2021
Meta Hill et al., Research Square, doi:10.21203/rs.3.rs-148845/v1 (Preprint) (meta analysis)
death, ↓75.0%, p=0.0002
Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection
Details   Meta analysis of 18 ivermectin RCTs with 2,282 patients showing faster viral clearance (dose and duration dependent), improved clinical recovery, and lower hospitalization and mortality. In six RCTs of moderate or severe infection, there ..
Jan 16
2021
Early Samaha et al., Viruses, doi:10.3390/v13060989 (results 1/16) Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon
Details   This study was retracted.
Jan 16
2021
Early Bukhari et al., medRxiv, doi:10.1101/2021.02.02.21250840 (results 1/16) (Preprint)
viral+, ↓82.4%, p<0.0001
Efficacy of Ivermectin in COVID-19 Patients with Mild to Moderate Disease
Details   RCT of relatively low risk hospitalized patients with 50 ivermectin and 50 control patients showing significantly faster viral clearance with treatment. 9 patients in the treatment arm were lost to followup compared with 5 in the control ..
Jan 13
2021
Review Kory et al., Frontiers in Pharmacology, doi:10.3389/fphar.2021.643369 (Review)
review
Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19
Details   Meta analysis of ivermectin clinical studies and natural experiments where ivermectin has been widely used, showing efficacy of ivermectin in prophylaxis and treatment of COVID-19. This paper was censored by the journal after acceptance .
Jan 12
2021
Late Okumuş et al., BMC Infectious Diseases, doi:10.1186/s12879-021-06104-9 (preprint 1/12)
death, ↓33.3%, p=0.55
Evaluation of the Effectiveness and Safety of Adding Ivermectin to Treatment in Severe COVID-19 Patients
Details   Small RCT for severe COVID-19 comparing the addition of ivermectin to SOC (low dose HCQ+AZ+favipiravir), with 30 treatment and 30 control patients in Turkey, showing lower mortality and faster clinical recovery. Authors also investigate t..
Jan 11
2021
PrEPPEP Chahla et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001433
m/s case, ↓95.2%, p=0.002
A randomized trial - intensive treatment based in ivermectin and iota-carrageenan as pre-exposure prophylaxis for COVID-19 in healthcare agents
Details   Prophylaxis RCT for ivermectin and iota-carrageenan in Argentina, 117 healthcare workers treated with ivermectin and iota-carrageenan, and 117 controls, showing significantly lower cases with treatment. There were no moderate/severe cases..
Jan 11
2021
N/A Bousquet-Melou et al., Preprint, doi:10.22541/au.161047848.80388481/v1 (Preprint)
dosing study
Large Impact of obesity on the disposition of ivermectin, moxidectin and eprinomectin in a canine model: relevance for COVID-19 patients
Details   Animal dosing study with an obese dog model concluding that ivermectin maintenance doses should be based on lean body weight and not the total body weight in obese subjects, while the loading dose should be based on the total body weight.