Chowdhury, 116 patient ivermectin early treatment RCT: 81% lower hospitalization [p=0.23], 46% improved recovery [p<0.0001], and 81% improved viral clearance [p=0.23] https://c19p.org/chowdhury
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A Comparative Study on Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin Therapy on COVID-19 Patients
et al., Eurasian Journal of Medicine and Oncology, doi:10.14744/ejmo.2021.16263, NCT04434144 (history)
Small 116 patient RCT with low-risk patients comparing ivermectin+doxycycline and HCQ+AZ, showing lower hospitalization, higher viral clearance, and faster symptom resolution and viral clearance with ivermectin+doxycycline. Mid-recovery resolution of symptoms is statistically significantly better with treatment, while other measures do not reach statistical significance. Instructions were to take ivermectin on an empty stomach, reducing lung tissue concentration. NCT04434144 (history).
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risk of hospitalization, 80.6% lower, RR 0.19, p = 0.23, treatment 0 of 60 (0.0%), control 2 of 56 (3.6%), NNT 28, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of no recovery, 46.4% lower, RR 0.54, p < 0.001, treatment 27 of 60 (45.0%), control 47 of 56 (83.9%), NNT 2.6, mid-recovery day 5.
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recovery time, 15.2% lower, relative time 0.85, p = 0.07, treatment 60, control 56.
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risk of no viral clearance, 80.6% lower, RR 0.19, p = 0.23, treatment 0 of 60 (0.0%), control 2 of 56 (3.6%), NNT 28, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), primary outcome.
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time to viral-, 4.3% lower, relative time 0.96, p = 0.23, treatment 60, control 56.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Chowdhury et al., 14 Jul 2020, Randomized Controlled Trial, Bangladesh, peer-reviewed, 6 authors, dosage 200μg/kg single dose, this trial compares with another treatment - results may be better when compared to placebo, this trial uses multiple treatments in the treatment arm (combined with doxycycline) - results of individual treatments may vary, trial NCT04434144 (history).
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