Retrospective 95 outpatients in Pakistan with strong clinical suspicion of COVID-19 (testing was not widely available), with 40 patients treated with ivermectin, showing significantly shorter duration of febrile illness with treatment. Most patients also received HCQ, AZ, zinc, and aspirin. Authors note that there was a treatment delay-response relationship.
duration of fever, 98.0% lower, relative time 0.02, p < 0.001, treatment 37, control 53, adjusted per study, logistic regression.
Ghauri et al., 12/15/2020, retrospective, Pakistan, South Asia, peer-reviewed, 6 authors, dosage 12mg days 1-6.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.