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Ivermectin study #120 of 124   Meta Analysis
9/23 Early treatment study
Mayer et al., Zenodo, doi:10.5281/zenodo.5525362 (Preprint)
Safety and efficacy of a MEURI Program for the use of high dose ivermectin in COVID-19 patients
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Retrospective 21,232 patients in Argentina, 3,266 assigned to ivermectin treatment, showing lower mortality with treatment. Greater benefits were seen for patients >40, and a dose dependent response was found.
Mayer et al., 9/23/2021, retrospective, Argentina, South America, preprint, 14 authors, dosage 540μg/kg days 1-5, mean prescribed dose.
risk of death, 55.1% lower, RR 0.45, p < 0.001, treatment 3266, control 17966, adjusted per study, odds ratio converted to relative risk, multiple logistic regression, Figure 3.
risk of ICU admission, 65.9% lower, RR 0.34, p < 0.001, treatment 3266, control 17966, adjusted per study, odds ratio converted to relative risk, multiple logistic regression, Figure 3.
risk of death, 27.6% lower, RR 0.72, p = 0.03, treatment 3266, control 17966, odds ratio converted to relative risk, unadjusted.
risk of ICU admission, 26.0% lower, RR 0.74, p = 0.13, treatment 3266, control 17966, odds ratio converted to relative risk, unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 124 studies   Meta Analysis
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