9/23 Early treatment study
et al., Zenodo, doi:10.5281/zenodo.5525362 (Preprint)
Safety and efficacy of a MEURI Program for the use of high dose ivermectin in COVID-19 patients
Safety and efficacy of a MEURI Program for the use of high dose ivermectin in COVID-19 patients
Retrospective 21,232 patients in Argentina, 3,266 assigned to ivermectin treatment, showing lower mortality with treatment. Greater benefits were seen for patients >40, and a dose dependent response was found.
Mayer et al., 9/23/2021, retrospective, Argentina, South America, preprint, 14 authors, dosage 540μg/kg days 1-5, mean prescribed dose.
risk of death, 55.1% lower, RR 0.45, p < 0.001, treatment 3266, control 17966, adjusted per study, odds ratio converted to relative risk, multiple logistic regression, Figure 3.
risk of ICU admission, 65.9% lower, RR 0.34, p < 0.001, treatment 3266, control 17966, adjusted per study, odds ratio converted to relative risk, multiple logistic regression, Figure 3.
risk of death, 27.6% lower, RR 0.72, p = 0.03, treatment 3266, control 17966, odds ratio converted to relative risk, unadjusted.
risk of ICU admission, 26.0% lower, RR 0.74, p = 0.13, treatment 3266, control 17966, odds ratio converted to relative risk, unadjusted.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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practical, effective, and safe means should be used. Elimination of COVID-19
is a race against viral evolution. No treatment, vaccine, or intervention is
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efficacy of any method increases the risk of COVID-19 becoming endemic; and
increases mortality, morbidity, and collateral damage. We do not provide
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